Cellular Vitality

Pleniage products to support cellular vitality: NAD+ levels, mitochondrial function and processes associated with longevity. PRO NAD+ NR Advanced Edition (nicotinamide riboside with resveratrol, berberine and quercetin) and NR 300 mg (nicotinamide riboside) in clinically studied doses, with full extract traceability.

Read the full Cellular Vitality guide →
Cellular Vitality

Products for your cellular vitality

  • PLENIAGE® PRO NAD+ NR Advanced Edition

    PLENIAGE® PRO NAD+ NR Advanced Edition

    Seven actives in two capsules a day: nicotinamide riboside chloride (NR, 100 mg), a form of vitamin B3 and NAD+ precursor, together with resveratrol, berberine, quercetin, vitamin C, hyaluronic acid and piperine.

    • 100 mg of NR, an NAD+ precursor
    • 294 mg of resveratrol, with berberine and quercetin
    • With vitamin C, hyaluronic acid and piperine
  • PLENIAGE® NR NAD+ NICOTINAMIDE RIBOSIDE | Nicotinamida Ribósido 300 mg

    PLENIAGE® NR 300 mg Single-component

    Pure Nicotinamide Riboside (NR) at 300 mg per capsule, with no secondary ingredients.

    • 300 mg of pure NR per capsule
    • Allows individualized dose adjustment
    • Pharmaceutical quality with traceability of the extract

Frequently asked questions

What is NAD+ and what is it for?

El NAD+ (nicotinamida adenina dinucleótido) es un cofactor esencial para más de 500 reacciones celulares, incluidas las que producen energía mitocondrial y las que regulan la actividad de las sirtuinas (proteínas asociadas a longevidad). Los niveles plasmáticos de NAD+ caen progresivamente con la edad: hasta un 50% hacia los 60 años. Restaurar NAD+ vía precursores como la NR es uno de los enfoques más estudiados en investigación de longevidad.

What is nicotinamide riboside (NR) and how does it work?

La NR es una forma de vitamina B3 que actúa como precursor directo del NAD+. La suplementación oral con NR ha demostrado en ensayos clínicos en humanos aumentar los niveles plasmáticos de NAD+ de forma segura y sostenida. A diferencia de otras formas de B3 (niacina, nicotinamida), la NR tiene mejor perfil de tolerancia y biodisponibilidad para este propósito.

What is the difference between PRO NAD+ NR Advanced Edition and NR 300 mg?

NR 300 mg is a single-ingredient product: 300 mg of nicotinamide riboside chloride a day, one capsule a day, one active and acacia fibre as the only excipient. PRO NAD+ NR Advanced Edition is the complete formula: 100 mg of nicotinamide riboside chloride plus resveratrol (294 mg), berberine (145.5 mg), quercetin (142.5 mg), vitamin C (77.6 mg), hyaluronic acid (72 mg) and piperine (4.75 mg), in two capsules a day. They are complementary within the range, not rivals: the single-ingredient product is about one molecule at a high dose; the Advanced Edition is about the whole formula. They are not taken together: the maximum daily dose of nicotinamide riboside chloride authorised for adults is 300 mg, and adding them would exceed it.

How long does it take to notice the effect?

La normalización de los niveles plasmáticos de NAD+ tras suplementación con NR es relativamente rápida (semanas). Las mejoras funcionales subjetivas (energía, recuperación, claridad) suelen aparecer entre las 4 y 12 semanas de uso continuado. Los efectos sobre marcadores de longevidad requieren más tiempo de uso y son objeto de investigación clínica activa.

Does NR have any contraindications?

The safety profile of NR at the studied doses (300-1000 mg/day) is good in trials of up to 12 weeks. The adverse effects described are mild and transient (occasional headache, digestive discomfort). Consult a healthcare professional if you take chronic medication or have medical conditions. NOT recommended during pregnancy or breastfeeding due to a lack of data.

Is it necessary to cycle it, or can it be taken continuously?

The clinical data available for 12 weeks of continuous use are favourable. For prolonged use, the prudent approach is to alternate cycles of 3-6 months with 4-week breaks, especially in order to assess individual response. Each biochemical profile responds differently: adjusting it with a healthcare professional is the most advisable approach.