Cellular Vitality

Pleniage products to support cellular vitality: NAD+ levels, mitochondrial function and processes associated with longevity. PRO NAD+ (NADH and polyphenols) and Nicotinamide Riboside (NR) in clinically studied doses, with full extract traceability.

Read the full Cellular Vitality guide →
Cellular Vitality

Products for your cellular vitality

  • PLENIAGE® PRO NAD+

    PLENIAGE® PRO NAD+

    Formula with NADH (reduced form of NAD+) and a matrix of polyphenols —resveratrol, quercetin and berberine—, with hyaluronic acid and vitamin C.

    • NADH (reduced form of NAD+)
    • Polyphenols: resveratrol, quercetin and berberine
    • With hyaluronic acid and vitamin C
  • PLENIAGE® NR NAD+ NICOTINAMIDE RIBOSIDE | Nicotinamida Ribósido 300 mg

    PLENIAGE® NR 300 mg Single-component

    Pure Nicotinamide Riboside (NR) at 300 mg per capsule, with no secondary ingredients.

    • 300 mg of pure NR per capsule
    • Allows individualized dose adjustment
    • Pharmaceutical quality with traceability of the extract

Frequently asked questions

What is NAD+ and what is it for?

El NAD+ (nicotinamida adenina dinucleótido) es un cofactor esencial para más de 500 reacciones celulares, incluidas las que producen energía mitocondrial y las que regulan la actividad de las sirtuinas (proteínas asociadas a longevidad). Los niveles plasmáticos de NAD+ caen progresivamente con la edad: hasta un 50% hacia los 60 años. Restaurar NAD+ vía precursores como la NR es uno de los enfoques más estudiados en investigación de longevidad.

What is nicotinamide riboside (NR) and how does it work?

La NR es una forma de vitamina B3 que actúa como precursor directo del NAD+. La suplementación oral con NR ha demostrado en ensayos clínicos en humanos aumentar los niveles plasmáticos de NAD+ de forma segura y sostenida. A diferencia de otras formas de B3 (niacina, nicotinamida), la NR tiene mejor perfil de tolerancia y biodisponibilidad para este propósito.

What is the difference between PRO NAD+ and NR 300 mg?

PRO NAD+ combines NADH (reduced form of NAD+) with a matrix of polyphenols (resveratrol, quercetin and berberine), hyaluronic acid and vitamin C, for integral cellular support. NR 300 mg is single-component Nicotinamide Riboside, pure at 300 mg per capsule, ideal for individually adjusting the dose or combining with other supplements. They are complementary approaches.

How long does it take to notice the effect?

La normalización de los niveles plasmáticos de NAD+ tras suplementación con NR es relativamente rápida (semanas). Las mejoras funcionales subjetivas (energía, recuperación, claridad) suelen aparecer entre las 4 y 12 semanas de uso continuado. Los efectos sobre marcadores de longevidad requieren más tiempo de uso y son objeto de investigación clínica activa.

Does NR have any contraindications?

The safety profile of NR at the studied doses (300-1000 mg/day) is good in trials of up to 12 weeks. The adverse effects described are mild and transient (occasional headache, digestive discomfort). Consult a healthcare professional if you take chronic medication or have medical conditions. NOT recommended during pregnancy or breastfeeding due to a lack of data.

Is it necessary to cycle it, or can it be taken continuously?

The clinical data available for 12 weeks of continuous use are favourable. For prolonged use, the prudent approach is to alternate cycles of 3-6 months with 4-week breaks, especially in order to assess individual response. Each biochemical profile responds differently: adjusting it with a healthcare professional is the most advisable approach.